Research Comparison
Pinealon (EDR) vs SS-31 (Elamipretide)
A side-by-side research comparison of Pinealon (EDR) and SS-31 (Elamipretide) drawn from Cedar Peptides' peptide database records.
Pinealon (EDR)
Pinealon (Glu-Asp-Arg/EDR) is a synthetic tripeptide bioregulator developed in Russia that demonstrates unique DNA-interaction capabilities for neuroprotection and cognitive enhancement. Research suggests benefits for traumatic brain injury recovery, age-related cognitive decline, and cellular aging processes through direct gene expression modulation. Studies have shown that Pinealon exerts neuroprotective effects through MAPK/ERK pathway modulation, reduced neuroinflammation, and enhanced NMDA receptor expression in hippocampal regions. Its ability to directly interact with DNA and influence gene expression makes it distinct from other peptide bioregulators.
SS-31 (Elamipretide)
SS-31, also known as Elamipretide or Bendavia, is a small aromatic-cationic tetrapeptide that selectively targets the inner mitochondrial membrane. Unlike traditional antioxidants that scavenge reactive oxygen species diffusely, SS-31 specifically binds to cardiolipin — a phospholipid critical for maintaining the structural integrity of the electron transport chain — protecting it from oxidative damage and restoring cellular energy production. This targeted mechanism makes SS-31 highly relevant in mitochondrial dysfunction, cardiovascular disease, and age-related decline. It has received regulatory approval for specific mitochondrial disorders, representing the first class of therapies directly targeting mitochondrial membrane integrity rather than downstream oxidative damage.
Reading a comparison
A comparison places two records side by side; it does not merge them. Each description above is drawn from that compound's own record, and the two were not necessarily characterised by the same methods, at the same time, or to the same level of detail. Before comparing any attribute, it is worth establishing that both records describe the substance you think they describe — names are not identifiers, and two entries sharing a name can differ in salt form, stereochemistry or the convention used to state a mass. Where a figure carries no method beside it, the comparison is between two reported numbers rather than between two measurements.