Scientific Reference
AOD-9604
Evidence profile: Predominantly preclinical
AOD-9604 is a modified 17-amino acid fragment derived from the C-terminal region of human growth hormone (hGH 176–191), with the addition of an N-terminal tyrosine residue. It was specifically engineered to isolate the lipolytic and anti-lipogenic properties of growth hormone while avoiding its anabolic and endocrine effects. Unlike full-length hGH, AOD-9604 does not bind to the growth hormone receptor, does not elevate IGF-1 levels, and does not impair glucose metabolism. This selective mechanism has made it a focus of research in obesity, fat metabolism, and cartilage repair, offering a more targeted metabolic profile without the systemic hormonal effects associated with growth hormone.
Mechanism of Action
AOD-9604 promotes fat metabolism by upregulating beta-3 adrenergic receptor activity, stimulating lipolysis and inhibiting lipogenesis in adipose tissue. Unlike full hGH, it does not interact with the growth hormone receptor, thereby avoiding downstream effects such as IGF-1 elevation, hyperglycemia, or cellular proliferation. This selective pathway enables targeted fat reduction without endocrine disruption.
Molecular Information
- Type: Modified hGH fragment (176–191)
- Length: 17 amino acids
- Molecular weight: 1815.1 g/mol
- Molecular formula: C78H123N23O23S2