Scientific Reference

BPC-157

Evidence profile: Preclinical, with limited uncontrolled human reports

BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide consisting of 15 amino acids, derived from a naturally occurring protective protein found in human gastric juice. It has been extensively studied for its regenerative, cytoprotective, and anti-inflammatory properties across multiple tissue types. Research has focused on its ability to accelerate healing in tendons, ligaments, muscles, and gastrointestinal tissues. Its mechanisms involve modulation of angiogenesis, collagen synthesis, and growth factor signaling, making it a broadly acting repair peptide with both local and systemic effects.

Mechanism of Action

BPC-157 promotes tissue repair through multiple pathways, including stimulation of angiogenesis, upregulation of growth factors, and enhancement of collagen synthesis. It improves vascularization at injury sites, supports fibroblast activity, and provides cytoprotective effects against tissue damage. Localized administration allows for increased exposure at target tissues, optimizing regenerative outcomes.

Molecular Information

Type: Pentadecapeptide
Length: 15 amino acids
Molecular weight: 1419.5 g/mol
Molecular formula: C62H98N16O22
CAS: 137525-51-0

Published Research

Injectable Peptide Therapy: A Primer for Orthopaedic and Sports Medicine Physicians
Mayfield CK et al. · The American journal of sports medicine · 2026 · Review
PMID 41476424 — View on PubMed
From Regeneration to Analgesia: The Role of BPC-157 in Tissue Repair and Pain Management
Yuan C et al. · International journal of molecular sciences · 2026 · Review
PMID 41898733 — View on PubMed
Effect of BPC-157 on Symptoms in Patients with Interstitial Cystitis: A Pilot Study
Lee E et al. · Alternative therapies in health and medicine · 2024 · Clinical
PMID 39325560 — View on PubMed
Protective effects of BPC 157 in rats with experimentally induced lower extremity ischemia-reperfusion injury
Yıldırım AK et al. · Scientific reports · 2026 · Preclinical
PMID 42204242 — View on PubMed