AICAR
AICAR research peptide. Third-party Certificates of Analysis are published for tested products and batches. Fast UK dispatch. For laboratory research use only.
Available sizes: 50 mg
AICAR (Acadesine)
An AMPK Signalling Compound Studied in Cellular Energy and Metabolic Regulation Research
AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide), also known as Acadesine, is a synthetic AMP analogue widely used in metabolic research. Scientists study AICAR for its ability to activate AMP-activated protein kinase (AMPK), a central enzyme responsible for regulating cellular energy balance.
AMPK functions as one of the body’s primary energy sensors. When activated, it helps coordinate metabolic pathways responsible for glucose utilisation, fatty acid metabolism, and cellular energy production.
Because AICAR is reliably converted inside the cell into a metabolite known as ZMP, it provides researchers with a consistent model for studying AMPK activation and metabolic signalling dynamics.
Why AICAR Is Studied
AMPK Pathway Activation: AICAR is widely used in laboratory studies investigating AMPK signalling, one of the primary pathways controlling cellular energy balance.
Glucose Transport Research: Researchers examine how AMPK activation influences glucose uptake and metabolic energy utilisation in cellular models.
Fatty Acid Metabolism: Studies frequently explore how AMPK signalling affects lipid metabolism and fatty acid oxidation pathways.
Cellular Energy Adaptation: AICAR is often used in experimental models studying how cells adapt to metabolic stress and changes in energy demand.
Scientific Research Context
AMP-activated protein kinase acts as a metabolic control switch that regulates how cells respond to fluctuations in energy availability. When cellular energy levels fall, AMPK signalling coordinates pathways that increase energy production while limiting energy-consuming processes.
Because AICAR can activate this pathway through intracellular conversion to ZMP, it has become a widely used compound in laboratory research examining metabolic signalling, bioenergetics, and cellular energy regulation.
Common Research Focus Areas
AMPK signalling pathway research
Glucose uptake and metabolic energy studies
Fatty acid oxidation and lipid metabolism research
Cellular bioenergetics and metabolic signalling models
Related Peptides
AICAR is often discussed within metabolic signalling research exploring cellular energy regulation and nutrient utilisation pathways.
Documentation and verification
Certificates of Analysis are published for tested products and batches. A certificate is a batch-specific record: it reports what was measured, by which method, on a stated date, against a batch identifier. It is evidence about the sample analysed at the time of analysis, and it is silent on attributes it does not list and on what has happened to the material since.
The batch number is the field that connects the document to a physical vial. Where the identifier on a vial does not appear on a certificate, the certificate does not describe that vial, however thorough the analysis behind it was. Batch records can be searched directly, and the guides below explain what each field establishes and what it does not.
- Verify a batchSearch a batch number for the certificate records published against it.
- How to read a certificate of analysisWhat each field reports, and the limits of what a certificate can establish.
- Certificate, specification and safety data sheetThree documents that answer three different questions.
- Storage and handlingWhat defined storage conditions mean, and why cold slows degradation.
- Batch numbers and traceabilityHow an identifier ties material to the analysis describing it.
Supplied for laboratory research use only. Not for human or veterinary use.